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Malaysia banks on palm oil vitamin E exports

Posted by Flora Sawita Labels: , , , , , ,

Walk into any pharmacy and you will see shelves lined with bottles of fish oil and evening primrose oil soft gels.

These yellow-coloured fish oil and evening primrose soft gels are imported and fortified with oilseed vitamin E called tocopherols.

But consumers may be better off with palm oil extracts. These orange-hued palm oil extracts are made in Malaysia and contain vitamins A and E, squalene and coenzyme Q10 that help boost our immune system.

It is a little known fact but palm oil extracts, which contain tocotrienols, are far more potent than fish oil supplements that are only fortified with oilseed tocopherols.

Vitamin E is actually a family of tocopherols and tocotrienols.

Malaysians are more familiar with imported fish oil than palm oil extracts because scientific studies on tocopherols are far more established than those for tocotrienols.

"There are not that many nutraceutical and cosmeceutical studies on tocotrienols compared with tocopherols," Ipoh-based Hovid Group managing director David Ho said.

Currently, less than one per cent of published studies on vitamin E focus on tocotrienols. Tocopherols are sourced from oilseeds such as soya oil, canola and sunflower, while tocotrienols are only available in high concentration in palm oil and rice bran oil. Both of these are grown in tropical countries.

Over the last decade or so, studies have shown that palm oil vitamin E, particularly the tocotrienols, is a far more potent antioxidant than tocopherols.

Preliminary studies prove tocotrienols can heal body cells and trigger cancerous cells to commit suicide. It is these unique biological activities in tocotrienols that show a promising future in finding cures for stroke, heart diseases and cancer.

Malaysia does not sell that much palm nutraceuticals locally because the export market is far more lucrative. A kilogramme of palm oil vitamin E sells for US$600 (RM2,160). Touted as "edible gold" among industry circles, the tocotrienol health supplement is the highest valued product in the sprawling palm oil supply chain.

Ho said his company exported more palm oil vitamin E than it sold locally. "We sell to 20 countries under the brand name Tocovid. Last year, we earned RM10 million in exports."

Another reason for the lack of awareness of heart-healthy palm oil extracts in Malaysia is the minimal advertising budget. The handful of Malaysian companies producing palm nutraceuticals prefer to spend their money on research and development rather than on marketing and advertisements.

"We spend RM5 million on research and development annually. Our health supplements speak for themselves," Ho said.

Tocovid is sold at a premium over other palm oil vitamin E soft gels because its patented SupraBio formulation boosts by three times the absorption rate into the bloodstream. "You would usually need to take vitamin E after a heavy meal like Nasi Kandar. But with our Suprabio formulation you can take Tocovid first thing in the morning on an empty stomach. It is that convenient," he said.

Palm oil vitamin E to prevent stroke

Posted by Flora Sawita Labels: , , , , , , , ,

Hovid takes heart from palm tocotrienols trials

IT IS a little known fact, but Malaysia is the world's biggest producer and exporter of tocotrienols, a potent form of vitamin E found abundantly in palm oil.

More importantly, Malaysia is also making medical progress in using palm oil extracts to lower risks of stroke and heart attacks and eventually, treat these degenerative diseases.

Leading this global race in finding natural sources to stem and treat major killer diseases are Ipoh-based Hovid Group, Universiti Sains Malaysia (USM) and the Malaysian Palm Oil Board (MPOB).

In an interview with Business Times, MPOB revealed that it is funding Hovid Group and USM to conduct clinical trials on the effectiveness of tocotrienols to prevent the onset of brain diseases like stroke.

The vitamin E family is made up of four variants of tocopherols and another four called tocotrienols.

"So far, there have only been animal tests. We're the first in the world to conduct human clinical trials on the neuroprotective properties of tocotrienols," MPOB director-general Datuk Dr Mohd Basri Wahid said.

"While our funds are limited, we see the potential of tocotrienols in protecting brain cells and easing clogged arteries. We managed to allocate RM4.48 million for this initiative," he added.

All in, there are 10 scientists conducting the clinical trials on 200 volunteers, which started in January 2008 and will conclude in January 2011. Since this trial is registered with the US National Institute of Health and the Food and Drug Authority, it is mandatory for the results to be published, be it positive or negative.

MPOB director of product development and advisory services Dr Kalanithi Nesaretnam, who is part of the research team, said MPOB has been studying palm tocotrienols since the 1980s. Incidentally, MPOB was also the first in the world to discover that the lesser known vitamin E family member, called tocotrienols, is a far more potent anti-oxidant than tocopherols.

Preliminary studies proved tocotrienols can heal body cells and trigger cancerous cells to commit suicide.

USM Professor Yuen Kah Hay concurred with Kalanithi. In explaining tocotrienols' unique biological activities, he cited studies by Ohio State University that proved tocotrienols (but not tocopherols) can prevent programmed death of brain cells under stress by suppressing key cell signals.

Subsequent experiments on genetically-modified mice which are prone to stroke also showed the tocotrienols could minimise cell damage.In view of the promising neuro-and-vascular-protective effects, the present study in Malaysia is conducted on volunteers with white matter lesion (WML), or oxygen-starved brain cells.

"From the brain scans, we can tell if there is WML, a form of subclinical brain infarct. This means the volunteer's brain vascular network is already unhealthy and at high risk of contracting stroke," Yuen said.

In this clinical trial, the professor said the researchers have been using tocotrienols, which have neuroprotective properties compared to their lame sister, alpha-tocopherol.

The researchers have also decided to use palm tocotrienols brand named Tocovid Suprabio because its patented formulation ensures optimum vitamin E absorption into the blood stream.

If tocotrienols proved to be able to prevent or reduce the occurrence of WML, then it can lower the risk of stroke. "Prevention," Yuen added, "is better than cure".

He paused and sipped on his glass of water. With a solemn expression, he revealed brain scans of 200 volunteers at USM's facilities in Hospital Kepala Batas showed half of them had WML. This supports latest statistics that stroke is Malaysia's number three killer after heart disease and cancer, with an average of five people dying of it every hour. Every year, it is estimated that 52,000 people suffer from stroke.

While the numbers are daunting enough to inflict paralysing fear, there is no need to panic. Hovid Bhd, which is spearheading this clinical trial, is optimistic of a positive outcome.

When asked to estimate how soon Malaysia can find the cure to neuro and cardiovascular diseases and formulate medication from palm tocotrienols, Hovid managing director David Ho envisioned a series of capital-intensive clinical trials on a bigger sampling of volunteers over a decade or so.

"We're fortunate that MPOB agreed to fund this clinical trial in Penang. But we cannot rely fully on MPOB as its financial resources are limited," he said. "We definitely need more public funding support to come up with more convincing data that palm tocotrienols can prevent and treat stroke and heart attacks," he added.

So far, the process that led to the joint clinical trial with USM and MPOB has not been easy. It took six months to obtain ethics approval from the medical fraternity before MPOB made the allocation.

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