Tocotrienols increasingly used in medicine
Posted by Labels: Bernard Dompok, palm oil, tocopherols, tocotrienols, Vitamin EWOULD YOU believe that palm oil vitamin E can help prevent death from stroke, heart attack and cancer?
When Plantation Industries and Commodities Minister Tan Sri Bernard Dompok was presented with a set of questions on palm oil vitamin E, he did not think too much of it until he received feedback from scientists at the Malaysian Palm Oil Board (MPOB).
He was pleasantly surprised by the far-reaching potentials of palm oil vitamins, particularly tocotrienols, in preventing stroke, heart ailments and cancer.
In a recent interview with Business Times at his office in Putrajaya, he said he was impressed that palm oil is now increasingly used in medical studies to treat diseases of aging. "I'm encouraged that more international scientists are tapping into the medical potentials of palm tocotrienols to prevent and eventually treat degenerative diseases like heart attacks, cancer and stroke," he said.
Prior to taking office at the Plantation Industries and Commodities Ministry 10 weeks ago, Dompok said he had always associated palm oil use only to cooking oil, oleochemicals and biodiesel.
Now that he is briefed on the promising medical benefits of palm oil vitamins, the minister eagerly awaits the results of the clinical trial being carried out at Hospital Kepala Batas by Hovid Bhd, Universiti Sains Malaysia and MPOB.
The clinical trial, conducted by 10 scientists on 328 volunteers, started in January last year. "We're now midway into this three-year research, it will conclude in January 2011," he said. "This clinical trial is of significance because it is bringing us a step closer in the prevention of cardiovascular diseases. "It is in the best interest of our nation to see this effort leading to more lives saved," the minister added.
To gain a deeper insight on the significance of this clinical trial, one has to understand that vitamin E is actually made up of a family of tocopherols and tocotrienols.In the past 50 years, the bulk of cardiovascular studies carried out in developed countries only focused on the effects of tocophe-rols because of the limited supply of tocotrienols.
Tocopherols is usually found in softoils like soya, canola and sunflower which are grown in cold climate countries while tocotrienols is only found abundantly in palm oil.
So far, preliminary scientific studies already suggest tocotrienols are 60 times more potent than tocopherols. It is also able to reduce bad cholesterols, induce cancer cells to commit suicide and slow down aging.
The Hospital Kepala Batas clinical trial is seeking to confirm if palm tocotrienols help protect against stroke and cardiovascular diseases. "If the findings at Hospital Kepala Batas amount to a medical breakthrough and the scientists need more funding to carry out bigger trials, we shall seek the allocation from the Finance Ministry," Dompok said.
Tocotrienols also demonstrate anti-cancer properties far superior than most other antioxidants. It not only prevents cancer from taking hold but actively blocks its growth and initiates apoptosis - a process where cancerous cells commit suicide.
Tocopherols, the more well-known but lame siblings in the vitamin E family, are not able to induce programmed death in cancer cells. Only the potent tocotrienols have this effect.
Dompok said MPOB scientists pointed out that tocotrienols are increasingly used to treat cancer. Second only to heart disease, breast cancer is the leading killer desease in women today.
Preliminary research by the University of Louisiana and University of Wisconsin in the US, University of Reading in the UK and the University of Western Ontario in Canada, showed tocotrienols can inhibit the growth of both estrogen-positive and estrogen-negative breast cancer cells while protecting healthy cells.
Another set of Canadian scientists at the University of Western Ontario proved tocotrienols are three times more potent than tamoxifen (standard treatment of breast cancer) in inhibiting growth of human breast cancer cells. The inhibitory effect is 45 times more potent when tocotrienol and tamoxifen are used together, suggesting a synergistic mechanism.
A five-year clinical trial at Hospital Kuala Lumpur which completed in 2006, sponsored by MPOB, involving 240 women with early breast cancer, showed a combination treatment of Tamoxifen and Tocovid SupraBio (bio-enhanced tocotrienol capsules provided by Hovid Bhd) resulted in higher survival rate and lower recurrence of breast cancer compared to Tamoxifen alone. "Since the 2006 clinical trial results, I'm told palm tocotrienols are increasingly being used by doctors to treat breast cancer patients," Dompok said.
When Plantation Industries and Commodities Minister Tan Sri Bernard Dompok was presented with a set of questions on palm oil vitamin E, he did not think too much of it until he received feedback from scientists at the Malaysian Palm Oil Board (MPOB).
In a recent interview with Business Times at his office in Putrajaya, he said he was impressed that palm oil is now increasingly used in medical studies to treat diseases of aging. "I'm encouraged that more international scientists are tapping into the medical potentials of palm tocotrienols to prevent and eventually treat degenerative diseases like heart attacks, cancer and stroke," he said.
Prior to taking office at the Plantation Industries and Commodities Ministry 10 weeks ago, Dompok said he had always associated palm oil use only to cooking oil, oleochemicals and biodiesel.
Now that he is briefed on the promising medical benefits of palm oil vitamins, the minister eagerly awaits the results of the clinical trial being carried out at Hospital Kepala Batas by Hovid Bhd, Universiti Sains Malaysia and MPOB.
The clinical trial, conducted by 10 scientists on 328 volunteers, started in January last year. "We're now midway into this three-year research, it will conclude in January 2011," he said. "This clinical trial is of significance because it is bringing us a step closer in the prevention of cardiovascular diseases. "It is in the best interest of our nation to see this effort leading to more lives saved," the minister added.
To gain a deeper insight on the significance of this clinical trial, one has to understand that vitamin E is actually made up of a family of tocopherols and tocotrienols.In the past 50 years, the bulk of cardiovascular studies carried out in developed countries only focused on the effects of tocophe-rols because of the limited supply of tocotrienols.
Tocopherols is usually found in softoils like soya, canola and sunflower which are grown in cold climate countries while tocotrienols is only found abundantly in palm oil.
So far, preliminary scientific studies already suggest tocotrienols are 60 times more potent than tocopherols. It is also able to reduce bad cholesterols, induce cancer cells to commit suicide and slow down aging.
The Hospital Kepala Batas clinical trial is seeking to confirm if palm tocotrienols help protect against stroke and cardiovascular diseases. "If the findings at Hospital Kepala Batas amount to a medical breakthrough and the scientists need more funding to carry out bigger trials, we shall seek the allocation from the Finance Ministry," Dompok said.
Tocotrienols also demonstrate anti-cancer properties far superior than most other antioxidants. It not only prevents cancer from taking hold but actively blocks its growth and initiates apoptosis - a process where cancerous cells commit suicide.
Tocopherols, the more well-known but lame siblings in the vitamin E family, are not able to induce programmed death in cancer cells. Only the potent tocotrienols have this effect.
Dompok said MPOB scientists pointed out that tocotrienols are increasingly used to treat cancer. Second only to heart disease, breast cancer is the leading killer desease in women today.
Preliminary research by the University of Louisiana and University of Wisconsin in the US, University of Reading in the UK and the University of Western Ontario in Canada, showed tocotrienols can inhibit the growth of both estrogen-positive and estrogen-negative breast cancer cells while protecting healthy cells.
Another set of Canadian scientists at the University of Western Ontario proved tocotrienols are three times more potent than tamoxifen (standard treatment of breast cancer) in inhibiting growth of human breast cancer cells. The inhibitory effect is 45 times more potent when tocotrienol and tamoxifen are used together, suggesting a synergistic mechanism.
A five-year clinical trial at Hospital Kuala Lumpur which completed in 2006, sponsored by MPOB, involving 240 women with early breast cancer, showed a combination treatment of Tamoxifen and Tocovid SupraBio (bio-enhanced tocotrienol capsules provided by Hovid Bhd) resulted in higher survival rate and lower recurrence of breast cancer compared to Tamoxifen alone. "Since the 2006 clinical trial results, I'm told palm tocotrienols are increasingly being used by doctors to treat breast cancer patients," Dompok said.
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